Mistresses follows the lives of four friends, Savi, Karen, April, and Josslyn, as they navigate their way through love, careers, and family while dealing with secrets and betrayal. The show is set in Los Angeles and features a strong female cast, including Alyssa Milano, Yunjin Kim, Rochelle Aytes, Jes Macallan Brett Tucker Jason George, and Rob Mayes.

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Some TV shows that have similar genres and were produced around the same time as Mistresses include Dead Boy Detectives, Avatar: The Last Airbender, Charmed, Imposters, Monk, Psych.