In the world's oldest profession, three stylish and intelligent women dare to dream big. Tired of being confined to the shadows, they set out to revolutionize their industry with modern marketing tactics. But as they climb the corporate ladder, they must confront the harsh realities of a business built on pleasure and power. Will their bold strategy pay off, or will they become just another statistic in a world where sex sells?

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Some TV shows that have similar genres and were produced around the same time as El Negocio include Dead Boy Detectives, The Big Door Prize, The Sympathizer, Bad Sisters, One Day, The Bear.