The New Adventures of Old Christine is a comedy series that follows the life of Christine Campbell, a recently divorced mother who runs a gym for women. Christine's ex-husband, Richard, has started dating a much younger woman named Christine, causing tension between the two. The show revolves around Christine's struggles to balance her personal and professional life while dealing with her neuroses and relationships. With the help of her sarcastic best friend and colleague, Barb, Christine navigates through various challenges including motherhood, love affairs, and mean school moms.

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Some TV shows that have similar genres and were produced around the same time as The New Adventures of Old Christine include Donny!, You're Whole, Shrinking, Jury Duty, The Office, Big Mood.