In the quiet town of San Rafael de los Penitentes, a series of mysterious murders takes place, each victim representing a different sign of the zodiac. Doctor Antonio Cruz, a respected member of the community, harbors a dark secret from his childhood that fuels his anger and resentment. As the body count rises, his sister, Laura, a police officer, and her ex-husband, Paul, the prosecutor, team up to solve the case. But the closer they get to the truth, the more they realize that nothing is as it seems in this gripping, twisted tale of revenge and deception.

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Some TV shows that have similar genres and were produced around the same time as Signs include Dead Boy Detectives, The Outsider, Sugar, Beyond Paradise, Boy Swallows Universe, Shining Girls.