A brilliant surgeon struggling with personal loss and professional challenges is approached by a tech billionaire with a terminal illness who wants her to investigate cases of reincarnation, near-death experiences, and hauntings. Despite initial skepticism, she agrees to take on the project, hoping to find proof that death is not the end. As she delves deeper into the mysteries of the human experience, she uncovers unexpected truths that challenge her beliefs and make her question what lies beyond. With the help of a team of experts, she embarks on a journey that could change the course of human understanding forever.

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Some TV shows that have similar genres and were produced around the same time as Proof include Fallout, 3 Body Problem, The Big Door Prize, Severance, The Walking Dead: The Ones Who Live, The Last of Us.