In an all-girls boarding school, five male students enroll for the first time. Excited to lose their virginity, they get caught peeping on the girls in the showers and are sent to the school's prison. The five boys must navigate their way through their strict and sexy female warden, who has a reputation for being ruthless. As they try to escape, they discover the dark secrets of the school's student council and the true purpose of the prison. Will they be able to escape or will they succumb to the warden's punishments? Based on the popular manga series by Hiramoto Akira, Prison School is a hilarious and controversial comedy-drama that explores the complexities of gender and sexuality.

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Some TV shows that have similar genres and were produced around the same time as Prison School include Bodkin, One Day, Hacks, The Boys, The Bear, Such Brave Girls.