A middle-aged family man, struggling with the onset of andropause, becomes obsessed with change and decides to pursue happiness. However, himself, he ends up making a complete mess of things. Amidst his quest for a new life, he must navigate complex relationships with his wife, children, and a cast of eccentric characters, all while trying to keep his sanity intact. Will he find happiness, or will his efforts only lead to more chaos?

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Some TV shows that have similar genres and were produced around the same time as Man on Pause include Avatar: The Last Airbender, 3rd Rock from the Sun, Meteor Garden, Henry Danger, That '70s Show, ALF.