Join Zak Bagans and his team as they embark on a spine-tingling journey to explore haunted locations across the United States, each with a dark history linked to infamous serial killers. From the home of Ted Bundy to the prison that held John Gacy, they seek to uncover whether the malevolent energy of these sadistic killers still lingers, leaving a trail of terror and paranormal activity in its wake. With a focus on documentation and investigation, this series delves into the mysteries of the supernatural, leaving no stone unturned in its quest for the truth.

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Some TV shows that have similar genres and were produced around the same time as Ghost Adventures: Serial Killer Spirits include Welcome To Murdertown, Beyond Belief: Fact or Fiction, Most Haunted, Help! My House Is Haunted!, Shock Docs, Ghost Brothers.