Dr. Megan Hunt, a brilliant neurosurgeon, is forced to give up her career after a devastating car accident. She redirects her skills to become a medical examiner, determined to solve the puzzle of who or what killed the victims. With her sharp instincts and vast medical knowledge, she takes on the criminal underworld and delivers justice for the deceased. However, her unorthodox methods often put her at odds with detectives and police protocol. Despite this, Megan remains steadfast in her pursuit of truth and justice for all.

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Some TV shows that have similar genres and were produced around the same time as Body of Proof include Poker Face, Monk, Dead Boy Detectives, Death in Paradise, A Killer Paradox, Bored to Death.