In a world where a pandemic has rendered all men impotent, high school student, Itsuki, is the exception who escaped it. He transfers to a very special high school, which turns out to be composed of 90% girls! Adam's Sweet Agony is a series that follows Itsuki's journey as he navigates this strange new world filled with girls who are not only attracted to him but also have their own secrets and motivations. As he tries to keep his secret safe, he finds himself caught up in a web of love, friendship, and betrayal. Will he be able to survive in this sweet agony?

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Some TV shows that have similar genres and were produced around the same time as Adam's Sweet Agony include Hetalia: World Stars, DARLING in the FRANXX, Jujutsu Kaisen, Lulu's Islands, Viva Piñata, Lunar Jim.