In the gritty streets of Philadelphia, eight-year-old Peter Flood witnesses his little sister's tragic death, sparking a cycle of violence and betrayal that will haunt him for decades to come. As he struggles to come to terms with his guilt and his father's vengeful past, Peter finds himself caught in a web of family secrets and criminal loyalties. Thirty years later, his cousin Michael has risen through the ranks of the family business, but their bond is put to the test when a brutal cycle of retribution threatens to tear them apart forever. Can Peter confront his demons and break free from the cycle of violence that has defined his family for generations?

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Some movies that have similar genres and were produced around the same time as Brothers by Blood include Lift, Rust Creek, The Batman, 21 Bridges, Death Wish, Lupin the Third: Goemon's Blood Spray.