Alyssa wakes up to a nightmare she can't remember. A stranger's home, a dead body, and no recollection of how she got there. As she tries to piece together the events of the previous night, Alyssa finds herself entangled in a web of mystery and deceit. With no one to trust and her life on the line, she must uncover the truth behind the one night stand that turned into a murder.

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Some movies that have similar genres and were produced around the same time as One Night Stand Murder include Killers of the Flower Moon, Where the Crawdads Sing, The Father, Wicked Little Letters, Under the Silver Lake, Burning.