In a post-apocalyptic world ravaged by a deadly pandemic, a former special forces soldier has retreated to a remote cabin in the woods to escape the horrors of his past. But when a mysterious woman appears at his doorstep seeking refuge, he is forced to confront his demons and join the fight against those who seek to exploit her unique blood for a cure. As he embarks on a dangerous journey to protect her and uncover the truth about his wife's murder, he discovers that his wife's killer is still alive – and now, he has a chance to avenge her death.

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Some movies that have similar genres and were produced around the same time as Last Man Down include Hypnotic, Fast X, Now You See Me 2, Skiptrace, Escape Room: Tournament of Champions, The Killer.

Last Man Down was released for streaming on February 16, 2022.