In feudal Japan, a young huntress named Hamaji stumbles upon a dangerous vendetta between a group of human-dog hybrids, the Fusé, and the ruthless shogun who seeks to eradicate them. With her brother, Hamaji joins the hunt for the Fusé, but her encounter with Shino, a mysterious Fusé, sets her on a path of self-discovery and conflict. As she navigates the treacherous world of Edo, Hamaji must choose between her life as a skilled huntress and her growing bond with Shino. Will she continue to follow her instincts ordefy her own nature to protect a creature she was meant to kill?

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Some movies that have similar genres and were produced around the same time as Fusé: Memoirs of a Huntress include Evangelion: 2.0 You Can (Not) Advance, BLAME!, Evangelion: 3.0 You Can (Not) Redo, Lupin the Third: Green vs. Red, Fate/stay night [Heaven's Feel] I. Presage Flower, Kite.