In the summer of 1990, Camp Kindlewood is forced to become co-ed, causing a clash of the sexes between the boys and girls. The camp director, Roger, tries to convince both sides that this is a great idea, but the head counselors, Dale and Amber, have other plans. They rally their respective sides and engage in a series of pranks and mischief, fueled by the camp caretaker, Coffee. As the battle of the sexes escalates, the boys and girls fight for dominance over their summertime home.

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Some movies that have similar genres and were produced around the same time as Boys vs. Girls include Good Mourning, The Intern, Prom Dates, Mean Girls, Ricky Stanicky, Bottoms.