Charly Matteï, a former mafia boss, lives a peaceful life with his family after retiring from the criminal underworld. However, his past comes back to haunt him when he's ambushed and left for dead with 22 bullets in his body. Miraculously, he survives and sets out to take revenge on his killers. As he hunts down the shooters, he's confronted with his criminal past and threats to his family. He visits the hit squad during a birthday celebration and announces that he'll kill each of them randomly at a time of his choosing. Marie Goldman, a policewoman investigating the shooting, is determined to clear up the murder of her husband, who was killed in the line of duty. Towards the end of the movie, Matteï makes a deal with Goldman to save his kidnapped son. In this gripping thriller, Charly Matteï must face his past and fight for justice while protecting his family from harm.

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Some movies that have similar genres and were produced around the same time as 22 Bullets include Unthinkable, Prisoners, The Departed, Nightcrawler, Lord of War, No Country for Old Men.

22 Bullets was released in theaters on October 8, 2010.