The Middle follows the daily lives of Frankie Heck, a middle-aged, middle-class woman, her husband Mike, and their three children, Axl, Sue, and Brick. The family resides in the small town of Orson, Indiana. Frankie narrates their experiences, struggles, and mishaps as they navigate life's ups and downs. With a stoic husband, a popular but laid-back teenage son, an enthusiastic but unsuccessful daughter, and a young son with odd behavioral quirks hinted at autism spectrum disorder—the series takes a lighthearted and comedic look at the challenges of parenting in today's world.

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Some TV shows that have similar genres and were produced around the same time as The Middle include What I Like About You, Jury Duty, Donny!, You're Whole, Big Mood, The Curse.