In a post-apocalyptic world,s Sarah Connor and her son John are on the run from both the government and machines from the future. They must fight to survive and prevent a nuclear war that could wipe out humanity. Sarah is haunted by visions of the future and determined to take down the technology that's hunting them. John, still struggling to come to terms with his destiny as the future leader of the resistance, must navigate his own path in a world that's against them. With the help of FBI agent James Ellison, they must stop the machines before it's too late.

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Some TV shows that have similar genres and were produced around the same time as Terminator: The Sarah Connor Chronicles include Fallout, 3 Body Problem, The Last of Us, Person of Interest, Legion, The Gifted.