In a world much like our own, but with a twist, a group of scientists led by the enigmatic Dr. Helen Magnus, protect and study strange and terrifying creatures known as Abnormals. Magnus, a brilliant scientist, seeks to unlock the mysteries behind their existence while keeping them safe from those who seek to harm them. But when her long-time client, Hal, a wealthy and powerful man, decides to end their secret relationship, Rebecca, a dominatrix and Hal's nemesis, will stop at nothing to keep the upper hand in a dangerous game of power and control. As the stakes rise and loyalties are tested, the balance of power shifts in a thrilling battle of wits and strength.

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Some TV shows that have similar genres and were produced around the same time as Sanctuary include Fallout, 3 Body Problem, The Last of Us, Person of Interest, Legion, The Gifted.