After their parents are killed in a car accident, five siblings must band together to navigate the challenges of growing up and staying together. As they take on the responsibility of running their family's restaurant, they face various struggles and heartaches, including alcoholism, cancer, and domestic violence. Despite the odds, they remain determined to stay a family and support each other through thick and thin.

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Some TV shows that have similar genres and were produced around the same time as Party of Five include A Man in Full, Lessons in Chemistry, Behind Her Eyes, Fleishman Is in Trouble, Euphoria, The Good Wife.