Parker Lewis is the coolest kid in school, surrounded by his quirky friends Mikey and Jerry. Together they navigate the absurd challenges of high school life, always trying to outsmart their nemeses - the uptight principal Grace Musso and Parker's mischievous little sister Shelly. With a blend of wit, humor, and pop culture references, this series takes a surreal and entertaining look at the ups and downs of adolescence.

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Some TV shows that have similar genres and were produced around the same time as Parker Lewis Can't Lose include Donny!, You're Whole, Shrinking, Jury Duty, The Office, Big Mood.