My Holo Love tells the story of a lonely woman, Han So-yeon, who struggles with face blindness and lives a reclusive life. She becomes the tester of an AI program called Holo whose humanlike appearance is identical to its creator Go Nan-do. As Han So-yeon develops a connection with Holo she begins experiencing feelings of love for the first time ever, but the cold personality Go Nan-do isn't exactly what she had in mind. This show explores how these three characters grow and change each other's lives.

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Some TV shows that have similar genres and were produced around the same time as My Holo Love include Dark Matter, Fallout, 3 Body Problem, The Last of Us, Silo, Severance.