In a world where monsters are a part of everyday life, they've started working in human resources. Lovebugs, Hormone Monsters, and other creatures are tasked with managing the romantic and professional lives of their human clients. They juggle their own personal dramas while trying to keep their clients happy. It's a comedy of errors and misunderstandings, as these monsters try to make sense of the complexities of human relationships. With their unique perspective, they bring a fresh approach to the ups and downs of life in the workplace.

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Some TV shows that have similar genres and were produced around the same time as Human Resources include Maid-Sama!, Scott Pilgrim Takes Off, Popeye: The Continuing Adventures, Meiji Tokyo Renka - Uncut, Inuyasha The Final Act, Ai Yori Aoshi.