In this spin-off of The Cosby Show, Denise Huxtable embarks on a new journey at Hillman College, a historically black university in Virginia. As she navigates campus life, she faces fresh challenges and responsibilities, along with her friends Whitley Gilbert and Dwayne Wayne. The show tackles real-life issues that were often avoided by The Cosby Show, such as HIV/AIDS. With a focus on student life and the experiences of black fraternities and sororities, A Different World offers a unique perspective on growing up and finding one's place in the world.

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Some TV shows that have similar genres and were produced around the same time as A Different World include Avatar: The Last Airbender, Knuckles, Wednesday, Full House, Young Sheldon, Heartland.