Four friends on a camping trip are drugged and kidnapped by a mysterious stranger. They wake up in a locked house with several other strangers, and are forced to inflict physical harm on each other in order to escape. The group must fill a jar with a chemical produced by their brains when in pain, but if they fail, their brains will be injected with a deadly poison. As they turn on each other in desperation, they discover that their captor has a sinister motive and that they are not the only ones in danger. Will they be able to escape, or will they succumb to the sick game of torture and pain?

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Some movies that have similar genres and were produced around the same time as Vile include Hidden, Exhibit A, 28 Weeks Later, A Serbian Film, The Taking of Deborah Logan, The Other Side of the Door.

Vile was released in theaters on July 23, 2012.