Sex and Death 101 is a dark comedy that follows the story of Roderick Blank, a successful businessman who receives an email containing a list of all the women he has slept with, including his fiancée Fiona Wormwood. As he sequentially beds the women on the list, he becomes increasingly obsessed and isolated, leading him to cross paths with a female vigilante known as Death Nell. The movie explores themes of sexuality, power, and fate, as Roderick's journey takes unexpected turns and he ultimately faces the consequences of his actions. With a cast of quirky characters and a blend of humor and drama, Sex and Death 101 is a thought-provoking and entertaining ride.

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Some movies that have similar genres and were produced around the same time as Sex and Death 101 include Georgia Rule, Stranger Than Fiction, No Reservations, (500) Days of Summer, Imagine Me & You, First Daughter.

Sex and Death 101 was released in theaters on June 15, 2007.