In a dystopian Los Angeles ravaged by the COVID-19 pandemic, a group of friends seek refuge in an online party filled with games, drinks, and drugs. But as they take ecstasy, things quickly spiral out of control, and their once-safe homes become a haven from a relentless, bloody attack on their senses. With the pandemic death toll rising and mass chaos descending upon the city, the friends must confront their own mortality and the harsh reality of their isolated existence.

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Some movies that have similar genres and were produced around the same time as Safer at Home include Orphan: First Kill, A Haunting in Venice, Into the Deep, The Passenger, 1 Must Fall, The Black Mass.