In the picturesque town of Cartagena, Colombia, a young man named Florentino Ariza falls deeply in love with Fermina Daza, a beautiful woman from a wealthy family. Despite their differences in social status, the two share a passionate romance through secret letters and stolen moments. But fate intervenes when Fermina's father discovers their relationship and sends her away, leading her to marry a wealthy doctor instead. Heartbroken but determined, Florentino vows to wait for Fermina's return and spend the rest of his days with her. As the years pass, Florentino's love remains steadfast, even as he engages in numerous affairs in an attempt to forget his beloved Fermina. When the doctor passes away, Florentino sees an opportunity to rekindle his romance with Fermina, but will she still have him? Set against the backdrop of a tropical paradise, Love in the Time of Cholera is a timeless tale of love, loss, and second chances.

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Some movies that have similar genres and were produced around the same time as Love in the Time of Cholera include Mona Lisa Smile, Larry Crowne, Silver Linings Playbook, Brokeback Mountain, One Day, No Reservations.

Love in the Time of Cholera was released in theaters on October 4, 2007.