In a subterranean orchard, two scientists grapple with the consequences of an unprecedented ecological disaster that has left their world in ruins. They discuss their experiences of exile, loss, and nostalgia, searching for meaning in a desolate future. As they explore their underground sanctuary, they confront the fragility of life and the importance of preserving hope in the face of uncertainty. Through their conversations, they reveal the impact of humanity's mistakes on the planet and the resilience of those who remain.

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Some movies that have similar genres and were produced around the same time as In Vitro include Prospect, The Osiris Child, Dune Drifter, Ejecta, Singularity, Alien: Battlefield Earth.