In the darkest corner of the universe, a group of marines must confront their deepest fears and faced off against an army of demons in a battle to save humanity. When a research facility on a remote Martian moon is overrun by horrific creatures from another dimension, the UAC sends in an elite unit of marines led by Lieutenant Joan Dark to contain the threat. But as they delve deeper into the heart of the facility, they soon realize that the demons are not just mindless beasts - they have a sinister purpose. With the help of Dr. Bennett Stone, an expert in ancient teleportation technology, Joan and her team must fight to stop the demons from opening a portal to hell and unleashing an eternal evil upon the Earth. But as they struggle to prevent the impending doom, they begin to suspect that one of their own may be working against them. Can Joan and her team overcome their personal demons and stop the apocalypse before it's too late?

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Some movies that have similar genres and were produced around the same time as Doom: Annihilation include Dune: Part One, The Cloverfield Paradox, The New Mutants, The Meg 2: The Trench, Empire of the Sharks, Triassic World.