In this comedic retrospective, archival footage and scripted sketches are combined to revisit the dreadful and occasionally delightful moments of 2021. The film takes a humorous look at the year's events, from the pandemic to politics, and features an ensemble cast, including Hugh Grant, Joe Keery, William Jackson Harper, Lucy Liu, Tracey Ullman, Samson Kayo, Stockard Channing, Cristin Milioti, and Diane Morgan.

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Some movies that have similar genres and were produced around the same time as Death to 2021 include Mean Girls, Dirty Grandpa, Booksmart, Joy Ride, Ricky Stanicky, Bottoms.

Death to 2021 was released for streaming on December 27, 2021.