In a world that may or may not be a computer simulation, a recently divorced and unemployed man named Greg (Owen Wilson) meets a mysterious woman named Isabel (Salma Hayek) who lives on the streets. Despite his initial skepticism, Greg becomes drawn into Isabel's wild conspiracy theory that the polluted and broken world around them is just a simulated reality. As they explore the possibilities of this idea, Greg begins to question what is real and what is not, and whether there might be some truth to Isabel's belief.

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Some movies that have similar genres and were produced around the same time as Bliss include Passengers, Little Fish, The Pod Generation, Next Exit, The Time Capsule, Needle in a Timestack.

Bliss was released for streaming on February 5, 2021.