In Miami, a mysterious suitcase threatens to blow up the city, and its inhabitants must navigate a series of misadventures and misunderstandings. A divorced dad (Tim Allen) and an unhappy housewife (Rene Russo) find themselves drawn to each other despite their children's rivalry during a wild game of "Killer." Two hitmen (Dennis Farina and Jack Kehler) hired to kill a man (Stanley Tucci) marked for death, two bumbling ex-convicts (Tom Sizemore and Johnny Knoxville), two FBI agents (Heavy D and Omar Epps) searching for a missing nuclear bomb, a homeless wanderer (Jason Lee) who loves Fritos, and a young Mexican housemaid (Sofia Vergara) add to the chaos. The movie features a star-studded cast and promises a hilarious and action-packed adventure with something for everyone.

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Some movies that have similar genres and were produced around the same time as Big Trouble include The Dukes of Hazzard, Hot Rod, Men in Black, Rush Hour, Hot Fuzz, Taxi.

Big Trouble was released in theaters on April 5, 2002.