Louise Farnt is a self-help obsessive looking for adventure. When she meets the charismatic but unstable Val Stone, she thinks she's found her ticket to excitement. But as their road trip takes a dark turn, Louise realizes she's in for the ride of her life - and it just might be her last. With Val's penchant for murder, this unlikely duo sets off on a thrilling and deadly adventure that will test the limits of their friendship and their will to survive.

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Some movies that have similar genres and were produced around the same time as A Serial Killer's Guide to Life include The Unbearable Weight of Massive Talent, Now You See Me 2, I Care a Lot, Maggie Moore(s), In Order of Disappearance, Lift.