Four young women, Jo, Cassandra, Shannon, and Kerrys, are brought together by a chance encounter with a pair of diamond thieves. Over the course of three days, they navigate two cities and a series of dangerous situations, all while trying to extricate themselves from the heist. As they work to retrieve the stolen diamonds, they discover unexpected truths about themselves and their relationships with each other. Will they be able to overcome their differences and work together to succeed, or will they fall victim to the dangerous world of crime and deception?

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Some movies that have similar genres and were produced around the same time as 4.3.2.1 include Ek Villain, Date Night (Extended Edition), Index Zero, Mortdecai PG-13, Rx (2005), Malice In Wonderland (2009).