Jeremy Wade, a seasoned angler and adventurer, embarks on a perilous journey to hunt down freshwater fish with a taste for human flesh. With the help of forensic science, he uncovers the truth behind the legendary creatures that lurk in the depths of rivers and lakes around the world. From Texas to Russia, Argentina to India, Jeremy travels far and wide to track down these monstrous fish and demonstrate their deadly capabilities. But will his quest for knowledge put him in harm's way? Join him on this heart-pumping voyage into the unknown.

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Some TV shows that have similar genres and were produced around the same time as River Monsters include Ivory Wars, On the Roam, The Curse of Oak Island, Primal Survivor: Over the Andes, Boss Hog, Outback Wrangler.