In 2176, Earth has colonized Mars, where 640,000 people live in harsh conditions. Lt. Melanie Ballard and her team are sent to transfer notorious criminal James "Desolation" Williams to the courthouse. They arrive at the abandoned city of Shining Canyon, where they find only Williams and a handful of prisoners alive. The rest of the town is filled with mutilated corpses. Meanwhile, in the depths of the open-pit mine, a strange ritual takes place, where thousands of warriors in a trance perform barbaric and bloody rites. The Battle between Good and Evil is about to begin.

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Some movies that have similar genres and were produced around the same time as Ghosts of Mars include Resident Evil, Alien Resurrection, Godzilla, Mothra and King Ghidorah: Giant Monsters All-Out Attack, Resident Evil: Apocalypse, Darkman III: Die Darkman Die, Starship Troopers 2: Hero of the Federation.

Ghosts of Mars was released in theaters on August 24, 2001.